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Non-GAAP Financial MeasuresCertain financial information is presented on both a reported and a non-GAAP basis. For the twelve months ended December 31, 2022, excluded charges primarily include the intangible asset impairment for GBA1 Gene Therapy (PR001) due to decreased utilization of savings card dynamics compared with Q4 2022 and, to a lesser extent, higher net interest expenses. Full Prescribing Information and Medication Guide for both medications.

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